Delta R&D is a bioengineering research center with a unique history. It was born out of individual research work begun in 1983 by Professor Giuseppe Marineo, a researcher and bioengineer, who advanced theories to reformulate the concept of disease (and its corresponding treatment) from a biophysical rather than biochemical point of view. The idea was to restructure the known features of both according to the principles of thermodynamics by means of an analysis and the detailed specification of the relations between entropy, disease, repair processes and ageing.
This new approach to the interpretation of the traditional aspects of medical science makes it possible to go from a highly heuristic system to an extremely conceptual and rationalized system, which can create models of disease and treatment so sophisticated as to render the experimental results highly predictable. If the latter are in line with the predictions they automatically validate the development model. Furthermore, the very name of the theoretical system developed entails a natural transition from reductionist methods to systems theory which, in the present research, takes the form of a powerful working tool capable of providing a framework for the development of therapies of practical utility.
Professor Marineo brought to medical science the research and development methodologies typical of engineering, in which the thoroughness of the preliminary theoretical work fully determines the expectations of the experimental verification of the method used. Since 1987, results from this basic research have been applied to the development of technologies capable of transforming theory into useful therapy.
Professor Marineo has focused his research on two significant areas within the medical field. The first has centered on regenerative processes and has led to the development of the Entropy Variation System (Delta-S). The other has concentrated on chronic and opiod-resistant pain and has resulted in the formulation of a new theoretical model for its treatment (Scrambler Therapy). Scrambler Therapy is at the core of Calmare® Pain Therapy Treatment.
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